The fractal geometry method is used to finely determine the structural fractal texture characteristics of the Yadu-Mangdong metallogenic belt in NW Guizhou Province. Combined with the structural ore-controlling characteristics and Fry analysis, the favorable ore prospecting area is delineated and the future ore prospecting direction of Pb-Zn resources in the study area is proposed. The results show that the statistical self-similarity of fault structure is good in the range of 3.371 to 26.965 km. The overall capacity dimension of faults is 1.6052 and the information dimension is 1.6051. The distribution of Pb-Zn deposits has two features, that is high fractal dimension and relative blocking-trap fluid area. Small Pb-Zn deposits are developed in the area that has capacity dimension greater than 1.29 and information dimension greater than 1.39, and medium-large Pb-Zn deposits are developed in area that has capacity dimension greater than 1.58 and information dimension greater than 1.42. The Pb-Zn deposits and their metal resources are significantly clustered and the fractal dimensions of spatial distributions are 1.0096 and 0.9313, respectively. According to the fractal dimension, structural ore-controlling characteristics and Fry analysis, the study area can be divided into four favorable metallogenic grades, of which grade I region has the highest ore prospecting potential. Such a region shows a spatially NW-trending distribution, including the newly discovered Zhugongtang Pb-Zn deposit.