The Baishuizhai pluton is one of the main ore-bearing wall rocks of the Zutongjian uranium deposit in the northwestern part of the Xiazhuang granite-related uranium ore filed, yet its petrogenetic mechanisms and its relationship with uranium mineralization are still unclear. Thus, in this study, we present zircon SHRIMP U-Pb ages, whole-rocks and mineral geochemical data for the Baishuizhai granite. Field and petrographic investigations show that the Baishuizhai granitic pluton was emplaced into the Xiazhuang granitic batholith, mainly composed of fine-grained two-mica granite and muscovite granite, and the zircon SHRIMP U-Pb dating reveals that both granites were formed during the Indochina period with ages of 229.4 Ma and 231.8 Ma, respectively. They show typical peraluminous S-type granitic geochemical characteristics that are high SiO
2 contents, total alkalis contents and ACNK values ( ≥ 1.1), low FeOt+MgO+TiO
2 contents and P
2O
5 contents, enriched in Rb, Th and U, depleted in Ba, Sr, P and Ti, and enriched in aluminum-rich minerals. Compared with the Xiazhuang granite, both types of granites in the Baishuizhai pluton show enriched in inherited zircon, higher SiO
2 contents and Rb/Sr ratios, but lower FeOt+MgO+TiO
2 contents, P
2O
5 contents, Zr/Hf ratios, and Fe
2+/(Fe
2++Mg) ratios of biotites, indicating that they were derived from low partial melting of reducing material-rich feldspathic meta-pelites, and are not formed by the differentiation evolution of the parent magma of the mafic meta-pelites-derived Xiazhuang granite. Furthermore, compared with the two-mica granite, the muscovite granite display significant tetrad REE patterns, lower REE, Zr/Hf ratios and Eu/Eu* values, indicating that an interaction of F-rich fluids with the magma occurred in the formation of the muscovite granite. Both types of granites in the Baishuizhai granitic pluton are enriched in uranium and can be important uranium-bearing granites in the region. Relative to the 2-mica granite in the Baishuizhai pluton, the muscovite granite is more enriched in uranium and more favorable to be uranium source rocks for hydrothermal uranium mineralization.