Abstract: The eastern Nanling mineralization zone is the world's leading tungsten-polymetallic ore concentration area. Many rounds of geological prospecting work make the region with a high degree of research and extreme difficulty in prospecting.The Nanshan W-Mo polymetallic deposit, which is a large granite-type deposit, was found by Nanjing Center, CGS during the investigation of tungsten polymetallic ores according to the model of“ the tungsten basement” under the“ five-floor structured wolframite-quartz veins” in this area in recent years. The results of drilling verified that under the quartz-vein type W-Mopolymetallic ore bodies exposed near the surface, at a deeper level of the Nanshan fine-grained two-mica granite, there develops a large-scale greisen type and granite type W-Mo polymetallic ore body. The Yanshanian Nanshan granite here is divided into three alteration zones, i.e., from top to bottom, the muscovitization zone, the chloritization zone and the K-feldspathization zone.The greisen type W-Mo ore body occurs in the muscovitization zone. The granite type W-Mo polymetallic ore body occurs in the chloritization and K-feldspathization zones. The major ore minerals are wolframite, molybdenite, sheelite, cassiterite, bismutinite,galena, sphalerite, chalcopyrite, pyrite, etc. A preliminary study indicates that the formation of the greisen type and granite type ore body might be related with the differentiation of deep-seated ore-bearing magma. The Nanshan W-Mo polymetallic deposit is characteristic of low-grade, large-scale and complex chemistry, with a W-Sn-Mo-Bi assemblage, enriched in Pb, Zn, Ag, Nb. The discovery of Nanshan deposit is not only a breakthrough of prospecting in the eastern Nanling, but also an important guide in the South China's W-Mo-polymetallic ore prospecting work as a whole.