Abstract: Based on the detailed seismic and well log data, utilizing work station and seismic interpretion software, taking Cenozoic strata in the east of Southeastern Hainan basin for an example, this paper studies the tectonic framework and sequence stratigraphy. Three types of tectonic slope-break zones were developed in the study area: the fault break-zone, the single slopebreak zone and the combined slope-break zone. Considerable amount of geological bodies in lowstand system tracts (LST) controlled by different tectonic framework were distinguished, including incised channel, basin floor fans, slope fans, low standwedge, which implies that their soure rocks were mainly derived from the east of the continental shelf in the basin. The characteristics and distribution of LST in the area correspond to the patterns of sequence stratigraphy framework, and sandbodies in LST could be available reservoirs. Directed by the theory of slope-break zones, this paper indicates the relationship between tectonic slope-break zones and reservoir distribution, and predicts the potential prospecting targets.