Abstract: The Hefei basin, located at the south boundary of NorthChina Block, is a largescale terrestrial basin formed during Mesozoic and Cenozoic period. The sedimentary features and tectonic evolution of Hefei basin were mainly controlled by Dabieshan orogenic belt and the TanLu fault zone. Based on the seismic and borehole data, 3D burial history analysis is carried out on MesoCenozoic strata of Hefei basin following the principle of backstripping. The overall thickness of Mesozoic and Cenozoic strata is more than 10 km in the Hefei basin, with Middle to Upper Jurassic strata constituting its major part. The analysis also shows that Hefei basin experienced 3 major tectonic erosion events since the Mesozoic. The location and migration history of the deposition center of different strata in the basin demonstrates that the deposition history of Hefei basin was jointly controlled by the Dabieshan orogenic belt and the adjacent TanLu fault zone. While Dabieshan orogenic belt played the dominant role in the Jurassic and Cenozoic, the largescale strikeslip movement of TanLu fault zone was the most important controlling factor in the Cretaceous.