Abstract: Genesis of Jiapigou gold deposits has been argued for a long time. Systematic tectono-geochemical analysis on the gold ore bodies, deposit belt and ore forming elements indicates that subduction and collision of the Paleo-Pacific plate with the North China plate during Mesozoic time resulted in generation of mantle-sourced and crust-sourced magmas and fluids. Mobilization and migration of ore-forming elements in the fluids yielded lateral Au, Cu zoning in regional scale and symmetric Au-Cu-Bi distribution within the one belt. Close relationship of controlling structure assemblage with features of primary halos, and stable isotope fractionation characteristics etc. show that the Jiapigou gold deposits were the products of Mesozoic tectono-magmatic and metallogenetic activity, in which both the mantle-sourced and crust-sourced fluids played an important role and ore forming materials were multiple-sourced.