The Kenli 10-1 oilfield is located in the northern slope of the Laibei low uplift. The Eocene Shabejie Formation of key reservoir evaluation is a complex fault-block reservoir, and its main oil-bearing interval is in the No.Ⅰand No.Ⅱoil layers of the Middle Es-3 (ie., the third Member of the Shahejie Formation), which are dominated by braided river delta deposits and highfrequency prograding delta deposits respectively. The delta is characterized by fast facies change and thin sand body reservoirs. Thus, conventional methods cannot accurately characterize the boundary of the sand body inside the prograding sand body, and the prediction accuracy is low. This study used seismic facies-controlled inversion to transform sedimentary facies characteristics on seismic profiles, and then stochastically simulated the spatial reservoir parameter based on the prior information of reservoir variables. We established a complete geostatistical variogram function and innovatively introduced adaptive regularization parameters for the noise model so that the stability and resolution of the inversion solution were improved. The application in the Kenli 10-1 oilfield shows that the inversion results are in good agreement with the staple pit, which can accurately and clearly characterize the boundary of a single prograding sand body and mudstone. This is consistent with the law of sedimentary patten of delta and achieves the purpose of accurately predicting moderately- and deep-buried oil and gas reservoirs. It is of great guiding significance for further deep oil and gas exploration and development in the future.