Abstract: Permian in Lower Yangtze Region is a typical sequence of mixed carbonate, chert and terrigenous clastics. Taking the Permian profiles in Chaoxian, Anhui as examples, the authors discuss its petrological and REE distribution characteristics. Seven sedimentary facies are divided, namely: restricted platform, open platform, continental slope, basin, delta, neritic and continental marginal lagoon facies, The Permian can be divided into seven third-order sequences. Four of them are type I sequences, other three agre type II sequences. Then the authors elaborate geochemical characteristics of these sequences. With the rising of sea level, δ13C is gradually increased and δ18O decreased. When sealevel changed, the high stand systems tract (HST) and the trangresivestand systems tract (TST) have different REE compositions. The total REE of TST is greater than that of HST. The trace element distribution characteristics in TST is different from that of HST. Based on above work, the authors conclude that geochemical parameters such as O and C isotopes, REE and trace elements are helpful to sequence analysis.