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SUBACUTE TOXICITY TEST ON THE COMBINED EFFECT OF STRONTIUM, BORON AND FLUORINE

Zhang Min1, Zhang Jing-rong2, Zhu Fa-hua2, Fan Xiao-ying1   

  1. 1. Department Environmental Science and Engineering; 2. Department of Earth Sciences, Nanjing University, Nanjing
  • Received:1997-12-20 Revised:1997-12-20 Online:1997-12-20 Published:1997-12-20

Abstract: Subacute toxicity of combined effect of strontium (Sr), boron(B) and fluorine(F) was tested on mice by drinking water containing Sr2+, B3+ and F-. The results showed that F content in bones and activity of alkaline phoshatase (Al, P)in kidney increased significantly(p<0.01)after the test of water containing 200 ppm F- for six months. ALP activity in serum also Increased sharply (P< 0.01)after 4.5 months, Sr and B added to the water with final concentration of 80 ppm and 100ppm respectively could induce the decrease of F content in bones and activity of Al P in kidney and serum. This indicates that Sr and B are both antidotes to F.