Abstract: The eastern Tianshan aera is rich in Au, Cu, Ni, and Mo mineral resources. Due to the large areas, it is time-consuming and relatively expensive to explore the mineral deposits by only using the traditional methods. The remote sensing approach, which call allow for synoptic and repetitive coverage of large areas in a cost-effective way, has become an attractive tool for exploring the mineral resources. In our study, based on the existing geological data, the LANDSAT-ETM image was used as a remote sensing technique, which is very rapid and sensitive for such an arid area with low vegetation cover. Firstly, the tectonic information was extracted by applying convolution filters to the ETM image. Based on the filter results, a potential mineralization area was determined. Next, in the area determined, the alteration information was extracted by combinging a ration of ETM bands with principal component analysis. Hence the target district for exploring was found, and an remote esnsing exploration model for Huangshan ploymetallic mineralization area was established.