Abstract: The Xianshi uranium deposit is located in the eastern part of the Guidong composite granite body．The uranium ore bodies occur in the intersection parts of the NWW-trending diabase dikes and the NEE-trending sillicification zones．The pyrite in the deposit is characterized by enrichment of radiogenetic uranium lead，(206Pb/204Pb)i= 18.756～23.883，(207Pb/204Pb)i= 15.676～15.932 and (208Pb/204Pb)i=38.530～38.938，main1y plotted in the range of the basement metamorphite lead．The calcite of uranium deposit hasδ13C values of –8.5～-3.1‰, which coincides with the mantle δ13C values(-5±2‰)．Theδ34S values of pyrite (-10.1～-8.3‰) is close to the δ34S values of pyrite in the granite (-10.9～-8.1‰) and markedly different from the δ34S values of pyrite in the diabase dike (-0.03～2.1‰)．Based on the lead，carbon and sulfur isotopic signatures．it is proposed that the ore-forming materials of the Xianshi uranium deposit display multiple．resourced characteristics．