Abstract: The data for 87Sr/86Sr, Rb/Sr and Sr contents of the acetic acid soluble components and insoluble components of shell bar section at southeastern Charhan saline lake, Qaidam Basin were presented. According to the environmental significance of Rb/Sr ratios of lake sediments, our data showed that, 87Sr/86Sr ratios can effectively indicate the catchment chemical weathering intensity and the paleoenvironmental changes of the deposit area; Correlation of 87Sr/86Sr with Sr/Ca and Sr/Ba ratios (salinity parameters) of the carbonate fractions indicates that the variation in carbonate 87Sr/86Sr values can be used to reflect the salinity of the water under formation condition. Based on chemical weathering intensities and salinity variations along the sequence, the environmental change history was reconstructed between 39.6 ka BP and 17.1 ka BP for the studied area. The high lake level was maintained between 33.2 ka BP and 27.4 ka BP, both the temperature and precipitation amount were higher than those of the present day. Till about 18 ka BP, the lake started to shrink, probably suggesting that the climate turned from a warmhumid interstadial into a colddry glacial climate.