Abstract: The study of biomineralization and corresponding mechanisms of environmental response can promote the development of biogeology in the interdisciplinary frontier and provide the scientific basis for the new significant pollutant control technology in the environmental fileds. The key scientific issue of this project is the mechanisms of mineral formation/decomposition controlled by life activities and the corresponding response to environmental factors. The main research scope includes the mechanisms of biomineralization, the environmental effects of biomineralization and the controlling theory and methods for biomineralization. The objectives of this project are to develop the theory of biomineralization from a multidisciplinary view, to discover the micro-mechanisms of heavy metal mineralization controlled by bacteria, to propose the principle of microorganism approach for the remediation of heavy metal pollution, to open the coupled mechanisms of POPs degradation by semiconductor minerals and bacteria and then construct a ternary system research method, to understand the decomposition mechanism of metallic sulfide mines accelerated by bacteria, to optimize a controlling means of mineral decomposition by bacteria influencing the eco-environment.