锶,硼和氟联合作用的亚急性毒理实验及环境意义

锶,硼和氟联合作用的亚急性毒理实验及环境意义

章敏张景荣朱法华范晓莹

[1]南京大学环境科学与工程系 [2]南京大学地球科学系

收稿日期:1997-12-20 修回日期:1997-12-20 出版日期:1997-12-20 发布日期:1997-12-20

SUBACUTE TOXICITY TEST ON THE COMBINED EFFECT OF STRONTIUM, BORON AND FLUORINE

Zhang Min1, Zhang Jing-rong2, Zhu Fa-hua2, Fan Xiao-ying1

1. Department Environmental Science and Engineering; 2. Department of Earth Sciences, Nanjing University, Nanjing

Received:1997-12-20 Revised:1997-12-20 Online:1997-12-20 Published:1997-12-20

摘要/Abstract

摘要： 本文以自由饮水给药方式进行了锶、硼和氟联合作用的亚急性实验，以探讨锶、硼对氟的拮抗作用。实验结果，给予小鼠200×l0^-6 F 六个月后，可使其骨氟含量显著升高(P<0.01)，肾碱性磷酸酶活力(ALP)显著增高(P<0.01)，4、5个月后血清碱性磷酸酶(ALP)活力亦显著增高(P<0.O1)，同时给予80×l0^-1 B3+、100×l0^-6Sr2+ 时，可以显著降低骨氟含量，抑制血清、肾碱性磷酸酶的活力，表明锶与硼对氟存在拮抗作用。

Abstract: Subacute toxicity of combined effect of strontium (Sr), boron(B) and fluorine(F) was tested on mice by drinking water containing Sr2+, B3+ and F-. The results showed that F content in bones and activity of alkaline phoshatase (Al, P)in kidney increased significantly(p＜0.01)after the test of water containing 200 ppm F- for six months. ALP activity in serum also Increased sharply (P< 0.01)after 4.5 months, Sr and B added to the water with final concentration of 80 ppm and 100ppm respectively could induce the decrease of F content in bones and activity of Al P in kidney and serum. This indicates that Sr and B are both antidotes to F.

章敏张景荣朱法华范晓莹. 锶,硼和氟联合作用的亚急性毒理实验及环境意义[J]. J4.

Zhang Min1, Zhang Jing-rong2, Zhu Fa-hua2, Fan Xiao-ying1. SUBACUTE TOXICITY TEST ON THE COMBINED EFFECT OF STRONTIUM, BORON AND FLUORINE[J]. J4.