Abstract: This region is demonstrated as a geochemical region with high fluorine through studies on the fluorine contents of soils, magmatic rocks and the Archean-Cenozoic strata geochemical profile. It is clarified that the Archean-Proterozoic ancient rock series with high fluorine in the Taishan-Yimenshan uplifted region is the material source of soil sediments, and that the Yellow River flood and heap many times (absorption of fluorine by clay minerals)accumulates and adds fluorine content in the soils according to heavy mineral comparative study and topography analysis. The study reveals that the water dissolved fluoride content in soils of this region is relatively high The fluorine is transferred into groundwater through natural water leachate and groundwater soak; and fluorine accumulation forms high fluoride groundwater region in sunk region of low-lying land between rivers because of water stagnation and evaporation concentration.