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J4 ›› 2011, Vol. 17 ›› Issue (1): 29-38.

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Characteristics of mineralized focuses in several breast diseases

WANG Chang-qiu,ZHAO Wen-wen,LU An-huai,XIONG Cui-e,MEI Fang,LIU Jian-ying    

  1. Key Laboratory of Orogenic Belts and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University
  • Received:2010-12-16 Revised:2011-02-13 Online:2011-03-20 Published:2011-03-20
  • Contact: Wang Changqiu, Associate Professor.
  • About author:Wang Changqiu, Associate Professor.


Mineralization  characteristics  of mineralized  focuses  in malignant breast  tumor, benign breast  tumor, breast
hyperplasia and mastitis frequently accompanied by calcification were investigated using optical microscope, environmental scan
electron microscope  (ESEM) and micro-FTIR  (Fourier  transform  infrared spectroscopy). The results  indicate  that morphology of
mineralization in different types of breast diseases are quite different. Collagen fibers and epithelial cells are closely related to the
mineralization. The calcification is incident to breast invasive carcinoma and breast carcinoma in situ on the old necroses in ducts.
Many calcified nano-bodies resembling psammoma body are formed on the collagen fibers in breast fibroadnoma. The mineralized
focuses with fibrous texture and sheaf structure occur between the collagen fibers in breast hyperplasia, on which many calcified
nano-balls are deposited. EDAX (energy dispersive X-ray analysis) results show that there may exist other calcium mineral (such
as calcium oxalate) deposition than calcium phosphates in breast hyperplasia. The calcified focuses with thick fibrous texture have
no special occurring positions in tissue of fat necrosis.

Key words: mineralized characteristics, breast invasive ductal carcinoma, breast fibroadnoma, breast hyperplasia, mastitis

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